Clavispora lusitaniae (formerly Candida lusitaniae) in the urogenital tract

Isolated from vaginas, Candida lusitaniae can cause peritonitis, meningitis, vulvovaginitis and urinary tract infection. Uncommon pathogen, many isolates are resistant to amphotericin B (AmB), fluconazole, itraconazole and 5-fluorocytosine. Vaginal C. lusitaniae has been treated with terconazole cream.​1​

 C. lusitaniae was first isolated from the digestive tract of warm-blooded animals and environmental isolations have been made from cornmeal, citrus peel, fruit juices, and milk from cows with mastitis.

The U.S. CDC has cautioned that the use of the teleomorph name Clavispora lusitaniae for the species can be misleading, because it does not “include the word Candida even though this organism is indeed a species of Candida“.

References

1Pappagianis D,  Collins MS,  Hector R,  Remington J. Development of resistance to amphotericin B in Candida lusitaniae infecting a human, Antimicrob Agents Chemother, 1979, vol. 16 (pg. 123-6)

Google ScholarCrossrefPubMed2Hadfield TL,  Smith MB,  Winn RE,  Rinaldi MG,  Guerra C. Mycoses caused by Candida lusitaniae, Rev Infect Dis, 1987, vol. 9 (pg. 1006-12)

Google ScholarCrossrefPubMed3Blinkhorn RJ,  Adelstein D,  Spagnuolo PJ. Emergence of a new opportunistic pathogen, Candida lusitaniae, J Clin Microbiol, 1989, vol. 27 (pg. 236-40)

Google ScholarPubMed4National Committee for Clinical Laboratory Standards (NCCLS). , Reference method for broth dilution antifungal susceptibility testing of yeasts, 1997Wayne, PANCCLS Approved standard M27-A

Google Scholar5Garcia-Martos P,  Diaz J,  Castano M,  Perez M,  Marin P. Peritonitis caused by Candida lusitaniae in patient on continuous ambulatory peritoneal dialysis (CAPD), Clin Nephrol, 1991, vol. 36 pg. 50 

Google ScholarPubMed6Yinnon A,  Woodin K,  Powell K. Candida lusitaniae infection in the newborn: case report and review of the literature, Pediatr Infect Dis J, 1992, vol. 11 (pg. 878-80)

Google ScholarCrossrefPubMed7Sanchez V,  Vazquez J,  Barth-Jones D,  Dembry L,  Sobel J,  Zervos M. Epidemiology of nosocomial acquisition of Candida lusitaniae, J Clin Microbiol, 1992, vol. 30 (pg. 3005-8)

Google ScholarPubMed8Sarma PS,  Durairaj P,  Padhye AA. Candida lusitaniae causing fatal meningitis, Postgrad Med J, 1993, vol. 69 (pg. 878-80)

Google ScholarCrossrefPubMed9Caillot D,  Casasnovas O,  Solary E, et al. Efficacy and tolerance of an amphotericin B lipid (Intralipid) emulsion in the treatment of candidemia in neutropenic patients, J Antimicrob Chemother, 1993, vol. 31 (pg. 161-9)

Google ScholarCrossrefPubMed10King D,  Froggatt JW,  Smith D,  Angelopolus CM,  Romagnoli M,  Mer WG. Molecular epidemiology of an amphotericin B, 5-FC resistant strain of Candida lusitaniae [abstract F-1], Program and abstracts of the 93rd annual meeting of the American Society for Microbiology (Atlanta), 1993Washington, DCAmerican Society for Microbiologypg. 527 

Google Scholar11Oleinik EM,  Della-Latta P,  Rinaldi MG,  Saiman L. Candida lusitaniae osteomyelitis in a premature infant, Am J Perinatol, 1993, vol. 10 (pg. 313-5)

Google ScholarCrossrefPubMed12Taylor GD,  Buchanan-Chell M,  Kirkland T,  McKenzie M,  Wiens R. Trends and sources of nosocomial fungemia, Mycoses, 1994, vol. 37 (pg. 187-90)

Google ScholarCrossrefPubMed13Rex JH,  Pfaller MA,  Barry AL,  Nelson PW,  Webb CD. Antifungal susceptibility testing of isolates from a randomized, multicenter trial of fluconazole versus amphotericin B as treatment of nonneutropenic patients with candidemia, Antimicrob Agents Chemother, 1995, vol. 39 (pg. 40-4)

Google ScholarCrossrefPubMed14Clancy CJ,  Nguyen MH,  Yu VL, et al. Fungemia caused by Candida lusitaniae: epidemiology, clinical manifestations, therapy, and outcome, Infect Med, 1996, vol. 13 (pg. 948-51)

Google Scholar15Nguyen MH,  Morris AJ,  Dobson ME, et al. Candida lusitaniae: an important emerging cause of candidemia, Infect Dis Clin Pract, 1996, vol. 5 (pg. 273-8)

Google ScholarCrossref16DiLorenzo DJ,  Wong G,  Ludmir J. Candida lusitaniae chorioamnionitis in a bone marrow transplant patient, Obstet Gynecol, 1997, vol. 90 (pg. 702-3)

Google ScholarCrossrefPubMed17Behar SM,  Chertow GM. Olecranon bursitis caused by infection with Candida lusitaniae, J Rheumatol, 1998, vol. 25 (pg. 598-600)

Google ScholarPubMed18Bren A. Fungal peritonitis in patients on continuous ambulatory peritoneal dialysis, Eur J Clin Microbiol Infect Dis, 1998, vol. 17 (pg. 839-43)

Google ScholarCrossrefPubMed19Huttova M,  Kralinsky K,  Horn J, et al. Prospective study of nosocomial fungal meningitis in children—report of 10 cases, Scand J Infect Dis, 1998, vol. 30 (pg. 485-7)

Google ScholarCrossrefPubMed20Krcmery VJr,  Oravcova E,  Spanik S, et al. Nosocomial breakthrough fungemia during antifungal prophylaxis or empirical antifungal therapy in 41 cancer patients receiving antineoplastic chemotherapy: analysis of etiology risk factors and outcome, J Antimicrob Chemother, 1998, vol. 41 (pg. 373-80)

Google ScholarCrossrefPubMed21Wendt B,  Haglund L,  Razavi A,  Rath R. Candida lusitaniae: an uncommon cause of prosthetic valve endocarditis, Clin Infect Dis, 1998, vol. 26 (pg. 769-70)

Google ScholarCrossrefPubMed22Krcmery VJr,  Mateicka F,  Grausova S,  Kunova A,  Hanzen J. Invasive infections due to Clavispora lusitaniae, FEMS Immunol Med Microbiol, 1999, vol. 23 (pg. 75-8)

Google ScholarCrossrefPubMed23Dorko E,  Kmet’ova M,  Marossy A,  Dorko F,  Molokacova M. Non-albicans Candida species isolated from plastic devices, Mycopathologia, 1999, vol. 148 (pg. 117-22)

Google ScholarCrossrefPubMed24Krcmery VJr,  Mrazova M,  Kunova A, et al. Nosocomial candidemias due to species other than Candida albicans in cancer patients: etiology, risk factors, and outcome of 45 episodes within 10 years in a single cancer institution, Support Care Cancer, 1999, vol. 7 (pg. 428-31)

Google ScholarCrossrefPubMed25Sood G,  Nyirjesy P,  Weitz MV,  Chatwani A. Terconazole cream for non-Candida albicans fungal vaginitis: results of a retrospective analysis, Infect Dis Obstet Gynecol, 2000, vol. 8 (pg. 240-3)

Google ScholarCrossrefPubMed26Luzzati R,  Amalfitano G,  Lazzarini L, et al. Nosocomial candidemia in non-neutropenic patients at an Italian tertiary care hospital, Eur J Clin Microbiol Infect Dis, 2000, vol. 19 (pg. 602-7)

Google ScholarCrossrefPubMed27Gordon SM,  Schmitt SK,  Jacobs M, et al. Nosocomial bloodstream infections in patients with implantable left ventricular assist devices, Ann Thorac Surg, 2001, vol. 72 (pg. 725-30)

Google ScholarCrossrefPubMed28Pietrucha-Dilanchian P,  Lewis RE,  Ahmad H,  Lechin AE. Candida lusitaniae catheter-related sepsis, Ann Pharmacother, 2001, vol. 35 (pg. 1570-4)

Google ScholarCrossrefPubMed29Minari A,  Hachem R,  Raad I. Candida lusitaniae: a cause of breakthrough fungemia in cancer patients, Clin Infect Dis, 2001, vol. 32 (pg. 186-90)

Google ScholarCrossrefPubMed30Kovacicova G,  Hanzen J,  Pisarcikova M, et al. Nosocomial fungemia due to amphotericin B-resistant Candida spp. in three pediatric patients after previous neurosurgery for brain tumors, J Infect Chemother, 2001, vol. 7 (pg. 45-8)

Google ScholarCrossrefPubMed31Christenson JC,  Guruswamy A,  Mukwaya G,  Rettig PJ. Candida lusitaniae: an emerging human pathogen, Pediatr Infect Dis J, 1987, vol. 6 (pg. 755-7)

Google ScholarCrossrefPubMed

  1. 1.
    Hawkins JL, Baddour LM. Candida lusitaniaeInfections in the Era of Fluconazole Availability. CLIN INFECT DIS. Published online January 15, 2003:e14-e18. doi:10.1086/344651
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