Eubacterium spp. contains anaerobic, non-spore-forming, gram-positive rods, rigid cell wall, motile or nonmotile, with several negative metabolic characteristics. Eubacterium is the second most common genus after the genus Bacteroides in the human intestine, being more common than the genus Bifidobacterium. The genus has important gut species.
Eubacterium species identification is typically based on phenotypic traits and requires experience and is time-consuming, thus many studies of human faecal flora composition have avoided this family.
Eubacterium form a part of the core human gut microbiome. The genus consists of phylogenetically, and quite frequently phenotypically, diverse species, making Eubacterium a taxonomically unique and challenging genus.
Several members of the genus produce butyrate, a critical element in energy homeostasis, colonic motility, immunomodulation and suppression of inflammation in the gut. Eubacterium spp. also carry out bile acid and cholesterol transformations in the gut, contributing to homeostasis.
Gut dysbiosis and a consequently modified representation of Eubacterium spp. in the gut, have been linked with various human disease states.
Eubacterium may be predictors of the endometrial microbiome1. Eubacterium is reported2,3 to be part of normal healthy vaginal flora, however this
Identified species of Eubacterium spp. in humans include:
- Eubacterium aggregans
- Eubacterium acidaminophilum
- Eubacterium angustum
- Eubacterium barkeri
- Eubacterium brachy
- Eubacterium budayi
- Eubacterium callanderi
- Eubacterium cellulosolvens
- Eubacterium combesii
- Eubacterium coprostanoligenes
- Eubacterium dolichum
- Eubacterium eligens
- Eubacterium hallii
- Eubacterium infirmum
- Eubacterium limosum
- Eubacterium minutum
- Eubacterium multiforme
- Eubacterium nitritogenes
- Eubacterium nodatum
- Eubacterium oxidoreducens
- Eubacterium plexicaudatum
- Eubacterium pyruvativorans
- Eubacterium ramulus
- Eubacterium rectale
- Eubacterium ruminantium
- Eubacterium saphenum
- Eubacterium siraeum
- Eubacterium sulci
- Eubacterium tarantellae
- Eubacterium tenue
- Eubacterium tortuosum
- Eubacterium uniforme
- Eubacterium ventriosum
- Eubacterium xylanophilum
- Eubacterium yurii
References2–5
- 1.Zornikov D, Voroshilina E, Plotko E, Islamidi D, Abakumova E, Koposova O. O-029 The Vaginal Microbial Predictors of the Endometrial Microbiota. Human Reproduction. Published online June 29, 2022. doi:10.1093/humrep/deac104.029
- 2.Spiegel C, Davick P, Totten P, et al. Gardnerella vaginalis and anaerobic bacteria in the etiology of bacterial (nonspecific) vaginosis. Scand J Infect Dis Suppl. 1983;40:41-46. https://www.ncbi.nlm.nih.gov/pubmed/6607521
- 3.Babu G. Comparative Study on the Vaginal Flora and Incidence of Asymptomatic Vaginosis among Healthy Women and in Women with Infertility Problems of Reproductive Age. JCDR. Published online 2017. doi:10.7860/jcdr/2017/28296.10417
- 4.Schwiertz A, Le Blay G, Blaut M. Quantification of Different Eubacterium spp. in Human Fecal Samples with Species-Specific 16S rRNA-Targeted Oligonucleotide Probes. Appl Environ Microbiol. Published online January 2000:375-382. doi:10.1128/aem.66.1.375-382.2000
- 5.Mukherjee A, Lordan C, Ross RP, Cotter PD. Gut microbes from the phylogenetically diverse genusEubacteriumand their various contributions to gut health. Gut Microbes. Published online August 23, 2020:1802866. doi:10.1080/19490976.2020.1802866
