Porphyromonas gingivalis is a prolific pathogen that is found mostly in the mouth, where it can cause some forms of periodontal disease. P. gingivalis has also been found in the digestive tract, respiratory tract, and in some women with bacterial vaginosis.
This species produces collagenase, which breaks down collagen, allowing the bacteria to enter skin cells, surviving even high doses of antibiotics.
P. gingivalis may contribute to conception issues in women. Lactobacillus gasseri, one of the possible major friendly microbes involved in a healthy vagina, was demonstrated in a mouse model to improve oral symptoms of periodontal disease and bone loss when P. gingivalis was present, offering an option for oral and vaginal dosing to clear P. gingivalis.
