Prevotella bivia is found in many human infections, including the vagina and reproductive tract, where it is known to contribute to bacterial vaginosis1–3 and pelvic inflammatory disease. P. bivia may also be found in healthy samples from the female reproductive tract and other areas of the body, such as the mouth.
P. bivia has been found in infected uterine and placental tissue and amniotic fluid during pregnancy complications, with colonisation correlated with increased risk of preterm birth.
In vitro studies may indicate a growth partnership between Gardnerella vaginalis and P. bivia using ammonia4. P. bivia produces ammonia, while G. vaginalis utilises ammonia.
Peptostreptococcus anaerobius may proliferate in the presence of P. bivia1.
P. bivia is oxygen-sensitive, thus any treatment containing oxygen may be successful. P. bivia, however, is not likely to be the only issue in the vagina during vaginal dysbiosis.
Possible early indicator of BV, works well in a team of other pathogens. Odour likely to be ammonia5. Can spread to uterus, becoming dangerous during pregnancy. 6
Relationship to human papillomavirus (HPV) when found in high numbers. May enter cervical cells, causing inflammation, being undetected by your immune system at times8.
References
- 1.Pybus V, Onderdonk AB. A commensal symbiosis betweenPrevotella biviaandPeptostreptococcus anaerobiusinvolves amino acids: potential significance to the pathogenesis of bacterial vaginosis. FEMS Immunology & Medical Microbiology. Published online December 1998:317-327. doi:10.1111/j.1574-695x.1998.tb01221.x
- 2.Muzny CA, Taylor CM, Swords WE, et al. An Updated Conceptual Model on the Pathogenesis of Bacterial Vaginosis. The Journal of Infectious Diseases. Published online August 1, 2019:1399-1405. doi:10.1093/infdis/jiz342
- 3.Atassi F, Brassart D, Grob P, Graf F, Servin AL. Lactobacillusstrains isolated from the vaginal microbiota of healthy women inhibitPrevotella biviaandGardnerella vaginalisin coculture and cell culture. FEMS Immunology & Medical Microbiology. Published online December 2006:424-432. doi:10.1111/j.1574-695x.2006.00162.x
- 4.Pybus V, Onderdonk AB. Evidence for a Commensal, Symbiotic Relationship between Gardnerella vaginalis and Prevotella bivia Involving Ammonia: Potential Significance for Bacterial Vaginosis. Journal of Infectious Diseases. Published online February 1, 1997:406-413. doi:10.1093/infdis/175.2.406
- 5.Hay PE. Bacterial Vaginosis as a Mixed Infection. In: Polymicrobial Diseases. 1st ed. ASM Press; 2002:1. https://www.ncbi.nlm.nih.gov/books/NBK2495/
- 6.Randis TM, Ratner AJ. Gardnerella and Prevotella: Co-conspirators in the Pathogenesis of Bacterial Vaginosis. The Journal of Infectious Diseases. Published online February 1, 2019:1085-1088. doi:10.1093/infdis/jiy705
- 7.STRÖMBECK L, SANDROS J, HOLST E, et al. Prevotella bivia can invade human cervix epithelial (HeLa) cells. APMIS. Published online March 13, 2007:241-251. doi:10.1111/j.1600-0463.2007.apm_512.x
| Condition type | Bacteria |
|---|---|
| Affected systems | Reproductive |
| Sexually Transmissible | |
| Genitourinary Incidence | common |
| Age group affected |
Microbial information
| Anaerobe / Aerobe | Anaerobe |
|---|---|
| Gram stain | Gram-negative |
| Best tests to detect |
|
| Pathogen of |
| Commensal of (Can naturally inhabit, but not necessarily as a healthy addition) |
|
| Optimal growth pH |
|
| Conditions correlated with |
|
| Cellular adherence capacities | Low |
| Found in healthy vaginas | Possibly |
| Biofilm-forming capacities |
|
| Cellular Morphology |
|
| Microbe Motility | Non-motile |
| Colony Colour |
|
| Substances Produced |
|
| Sexually Transmissible | Possibly |
What are the symptoms of Prevotella bivia in the vagina?
What causes Prevotella bivia in the vagina?
- No causes found for Prevotella bivia in the vagina, yet.
What are the risk factors associated with Prevotella bivia in the vagina?
How do you diagnose Prevotella bivia in the vagina?
How do you treat Prevotella bivia in the vagina?
Treatments for Prevotella bivia in the vagina are only for practitioners and people who purchased the book Killing BV and Killing BV for men.
Which treatments are likely to be ineffective for Prevotella bivia in the vagina?
What complications are associated with Prevotella bivia in the vagina?
- No complications found for Prevotella bivia in the vagina, yet.
References
Finegold SM. Anaerobic Gram-Negative Bacilli. In: Baron S, editor. Medical Microbiology. 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Chapter 20. Available from: https://www.ncbi.nlm.nih.gov/books/NBK8438/ https://www.ncbi.nlm.nih.gov/books/NBK8438/Patterson JL, Stull-Lane A, Girerd PH, Jefferson KK. Analysis of adherence, biofilm formation and cytotoxicity suggests a greater virulence potential of Gardnerella vaginalis relative to other bacterial-vaginosis-associated anaerobes. Microbiology. 2010;156(Pt 2):392-399. doi:10.1099/mic.0.034280-0 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890091/Acid Production by Vaginal Flora In Vitro Is Consistent with the Rate and Extent of Vaginal Acidification E. R. Boskey, K. M. Telsch, K. J. Whaley, T. R. Moench, R. A. Cone Infection and Immunity Oct 1999, 67 (10) 5170-5175; DOI: 10.1128/IAI.67.10.5170-5175.1999 https://iai.asm.org/content/67/10/5170
