A study[1. Arzneimittelforschung. 2011;61(4):260-5. doi: 10.1055/s-0031-1296197. Efficacy of vitamin C vaginal tablets in the treatment of bacterial vaginosis: a randomised, double blind, placebo controlled clinical trial. Petersen EE1, Genet M, Caserini M, Palmieri R.] looked into the use of silicon-coated vitamin C for bacterial vaginosis treatment in a randomised, double blind, placebo controlled clinical trial.
Dose and treatment
A dose of 250mg of vitamin C (ascorbic acid) was given to women with BV, to insert vaginally for six days, once per day.
Results
There were several results categories.
- Intent to treat (ITT) population, BV was resolved in 55 per cent of the women and in 26 per cent of those given the placebo.
- In the per-protocol (PP) population, the cure rate was 66 per cent for the vitamin C group and 27 per cent with the placebo.
- A subset of patients with centralised evaluation of the vaginal swab, cure in ITT sat at 86 per cent with vitamin C and 8 per cent of placebo patients.
- A subset of patients with centralised evaluation of the vaginal swab, cure in PP sat at 86 per cent with vitamin C and 6 per cent of placebo patients.
Conclusion
The researchers state that both vitamin C and placebo were well tolerated and there was no difference in safety profile between the groups. Vitamin C coated with silicon was determined to be an effective and safe treatment/management strategy for BV.
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