Darier disease is an inherited keratinisation disorder that presents with wart-like spots across the body, with the genitals frequently involved.1,2
There is a sub-version of this disease known as linear or segmental-form Darier disease, where the spots are localised to one side of the body, and not widespread like in usual Darier disease.
Symptoms of Darier disease
- Wart-like spots, often yellow and hard
- Spots can be greasy
- Spots can smell very strong
- Appears on scalp, forehead, upper arms, chest, back, knees, elbows, behind the ear
- May impact mucous membranes (mouth, vagina)
- Red and white streaks on textured nails
- Small pits in the palms and soles of the feet
This condition typically appears in the teens, with flare-ups and calm periods coming and going. Summer usually sees more blemishes, with heat, humidity, sweat and friction. Rubbing, scratching, UV light and some medicines also make this condition worse.3
Mild intellectual disabilities are linked with Darier disease, which may be genetic, however there may be social problems associated with this disease, since it is physically obvious.4
Keratinisation of the skin is disrupted due to a mutation of a gene on band 12q23-24.1, with incidence relatively widespread. It is found in Britain and Europe in about 1 in 100,000 and 1 in 30,000 people respectively.5
The inner workings of muscles are affected, particularly the relaxation and contraction of a muscle.6
References
- 1.Sehgal VN, Srivastava G. Darier’s (Darier–White) disease/keratosis follicularis. Int J Dermatology. Published online June 10, 2004:184-192. doi:10.1111/j.1365-4632.2004.02408.x
- 2.Alsharif SH, Alesa D, Baabdullah A. Type 1 Segmental Darier Disease: Case Report and Discussion of the Treatment Options. Case Rep Dermatol. Published online September 11, 2020:159-167. doi:10.1159/000509177
- 3.Hanna N, Lam M, Fleming P, Lynde CW. Therapeutic Options for the Treatment of Darier’s Disease: A Comprehensive Review of the Literature. J Cutan Med Surg. Published online November 28, 2021:280-290. doi:10.1177/12034754211058405
- 4.Curman P, Jebril W, Larsson H, Bachar-Wikstrom E, Cederlöf M, Wikstrom JD. Darier disease is associated with neurodegenerative disorders and epilepsy. Sci Rep. Published online March 26, 2024. doi:10.1038/s41598-024-57779-4
- 5.MUNRO CS. The phenotype of Darier’s disease: penetrance and expressivity in adults and children. Br J Dermatol. Published online August 1992:126-130. doi:10.1111/j.1365-2133.1992.tb08044.x
- 6.Gharaeinejad K, Eftekhari H, rafiei rana, Darjani A, Alizadeh N. Inflammatory myopathies in a patient with Darier’s disease, a possible association. Caspian J Intern Med. Published online January 2018. doi:10.22088/cjim.9.2.201
Specially formulated probiotic for vaginal application to promote a healthy vaginal microbiome.
Unique, comprehensive BV, AV and 'mystery bad vag' treatment guide, one-of-a-kind system, with effective, innovative treatments.
