Review: Multi-Gyn Active Gel (Actigel) – how and why it works

TL;DR

Multi-Gyn Active Gel (Actigel) uses the anti-adhesive properties of 2QR, derived from aloe vera, to prevent pathogenic microbes from adhering to vaginal or vulvar cells, without harming beneficial lactobacilli. This review explores its effectiveness, side effects, and the science behind its unique mechanism, offering an insight into its use as a management strategy for maintaining vaginal health.

The active ingredient, 2QR, in Multi-Gyn Active Gel (formerly Actigel) is an anti-adhesive developed from aloe vera (Aloe barbadensis) that binds to the adhesins on the cell surface of pathogenic microorganisms. This thereby blocks the microbe’s adhesive capacities, neutralising a bacteria’s ability to stick to vaginal or vulvar cells.

Multi-Gyn Actigel works on harmful microbes and does not directly affect microbial viability, which means it doesn’t actually kill the bacteria, it just makes them unable to stick to the walls of the vagina.

Multi-Gyn Actigel doesn’t affect healthy lactobacilli and can work on the skin, vagina, and mouth, or wherever pathogens are an issue.

Multi-Gyn Active Gel has a pH of 4.1, which is within the range of a healthy vagina (3.5 – 4.5). This makes it inappropriate for those wishing to conceive and should be avoided during active conception attempts (leave 24 hours on each side).

Ingredients in Multi-Gyn Active Gel

  • Galactoarabinan polyglucoronic acid crosspolymer
  •  Xanthan gum
  •  Glycerin
  •  Caprylyl glycol

Side-effects of Multi-Gyn Active Gel

There are no known side effects of this product, but that doesn’t mean you won’t have any side effects. If you experience irritation, discontinue use.

Who makes Multi-Gyn Active Gel?

Multi-Gyn is a women’s health brand developed by BioClin, a Dutch company founded in 1989. BioClin develops medical devices and personal care products.

My Vagina’s thoughts on Multi-Gyn Active Gel

This product is not a cure or treatment for vaginal bacterial imbalances like bacterial vaginosis, aerobic vaginitis, or other vulvovaginal infections. It may alleviate some odour or discomfort in some people.

If you have vaginal flora imbalances, using this product may be useful, but is not a fast or necessarily long-lasting treatment. Multi-Gyn Balance Active may be a useful management strategy between bigger treatments that address the underlying causes of vaginal microbiome disturbances.




Jessica Lloyd - Vulvovaginal Specialist Naturopathic Practitioner, BHSc(N)

Jessica is a degree-qualified naturopath (BHSc) specialising in vulvovaginal health and disease, based in Melbourne, Australia.

Jessica is the owner and lead naturopath of My Vagina, and is a member of the:

  • International Society for the Study of Vulvovaginal Disease (ISSVD)
  • International Society for the Study of Women's Sexual Health (ISSWSH)
  • National Vulvodynia Association (NVA) Australia
  • New Zealand Vulvovaginal Society (ANZVS)
  • Australian Traditional Medicine Society (ATMS)
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