Researchers developed a biofilm model for Gardnerella vaginalis biofilms in the lab, and screened compounds to see what could prevent biofilm formation and what could dissolve an established biofilm.
Antibiotics
Metronidazole and tobramycin could prevent biofilm formation, but had no effect on an established biofilm.
SCAA
Amphoteric tenside sodium cocoamphoacetate (SCAA) disintegrated existing biofilms, reducing biomass by 51 per cent and viability by 61 per cent. The impact of antibiotics improved the biomass yet again, increasing the impact by 40 per cent for biomass and 61 per cent for viability.
What is SCAA?
Sodium cocoamphoacetate is a biodegradable mild amphoteric surfactant made from fatty acids of coconut oil, used in cosmetics.
Why can’t we use SCAA?
At the moment, you can’t buy SCAA in a form that is safe to use in the vagina. It is a surfactant, which comes with safety warnings – do not allow contact with eyes or skin, and wash thoroughly after handling. Manufacturers advise using gloves and goggles when handling.
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