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Embarking on a low-histamine experiment requires fortitude, perseverance, and a strict adherence to diet and supplements for at least two weeks. This article guides you through understanding histamine’s effects, managing intake through diet, enhancing elimination via supplements, and stabilising mast cells to reduce histamine production. It covers the importance of specific nutrients like Vitamin D, Zinc, and probiotics in managing histamine levels, offering practical advice for those looking to alleviate symptoms through a low-histamine lifestyle.