Understanding and using phyto-oestrogens in food

  • Jessica Lloyd Lead Naturopath and founder of My Vagina clinic
    Author: Jessica Lloyd
    Senior Naturopath | BHSc(N) | ISSVD, ISSWSH, BSSM, ATMS

Phytoestrogens are plant chemicals, flavonoids, that behave like oestrogen in humans. These plant oestrogens are about 300 times weaker than human estrogen, which can augment the estrogenic effect in the body by weakening regular estrogen (in case of excess) or increasing it from low estrogen (say in postmenopause)​1​.

We can use phytoestrogens for a weak and strong relative effect, depending on the person’s needs. We would also be cautious in using phytoestrogens in men, babies, children and those without estrogen imbalances.

Some Sciencey Stuff
Most phytoestrogens are flavonoids, with the most potent being coumestans and isoflavones (genistein and daidzein). Most research has been done on isoflavones, which are found in soy and red clover. Lignan - not a flavonoid - is also a phytoestrogen. These are phenolic phytoestrogens.

Some other molecules, plant steroids and terpenoids, may also have an estrogenic effect.

Sources of phytoestrogens

While many plants contain phytoestrogens, only some contain enough that we’d use them medicinally.

Foods with phytoestrogens include:​2,3​

  • Flax seeds (high in lignans)
  • Legume seeds (soy, beans, peas, high in isoflavones)
  • Soy products (tofu, tempeh, soy milk, soybeans, high isoflavones)
  • Sesame seeds
  • Wheat
  • Berries
  • Oats
  • Barley
  • Dried beans
  • Lentils
  • Rice
  • Alfalfa
  • Mung beans
  • Apples
  • Carrots
  • Wheat germ
  • Ricebran
  • Soy-linseed bread

The amount of phytoestrogens in a particular food varies depending on processing. An intake of 45mg of phytoestrogens daily may have a stabilising effect on hormones.

Searchable phytoestrogens food list

Plant species (Common name)μg/100 g dry weightLevels
Plum5Very Low
Wheat (white meal)8Very Low
Banana10Very Low
Apple12Very Low
Oatmeal13Very Low
Potato (peeled)16Very Low
Lentil23Very Low
Pea27Very Low
Cabbage33Very Low
Tritacle (meal)35Very Low
Wheat (wholegrain)36Very Low
Cabbage, Turnip-rooted43Very Low
Poppy seed51Very Low
Tritacle (wholegrain, wheat variant)52Very Low
Barley (wholegrain)80Low
Barley bran85Low
Onion91Low
Pistachio nut96Low
Beetroot100Low
Almond111Low
Cauliflower111Low
Rye meal (wholegrain)112Low
Wheat bran121Low
Hazelnut123Low
Paprika124Low
Rasberry139Low
Sharon145Low
Cabbage, Red160Low
Red currant165Low
Walnut173Low
Oat bran179Low
Witloof/Endive190Low
Cloudberry203Moderate
Caraway seed235Moderate
Chickpea/Garbanzo bean250Moderate
Black-eyed pea/Cow pea255Moderate
Cashew nut261Moderate
Rye bran299Moderate
Black gram bean361Moderate
Carrot (skin on)370Moderate
Garlic380Moderate
Kidney bean396Moderate
Black currant398Moderate
Peanut420Moderate
Broccoli451Moderate
American groundnut (potato bean)511Moderate
Pigeon pea517High
Clover seed518High
Zuccini (skin on)817High
Blueberry835High
Sesame seed852High
Cranberry1054High
Strawberry1210High
Lingonberry1510High
Tea, Yellow label tea-bag2591Very High
Sunflower seed2600Very High
Tea, Earl Grey tea (Oriental tea mixture)3212Very High
Kudzu leaf3371Very High
Tea, Pure Lapsang Souchong tea (China)3520Very High
Tea, China Gunpowder3672Very High
Pumpkin (peeled)3874Very High
Tea, Japan Sencha Green tea4075Very High
Tea, Nippon Sencha Green tea5565Very High
Tea, Prince of Wales, tea-bag5768Very High
Tea, China Green tea5965Very High
Tea, Green8000Very High
Black tea8500Very High
Soy bean88843Extremely High
Kudzu root197631Extremely High
Flaxseed370987Extremely High
Flaxseed (crushed)547300Extremely High

Herbal medicines with phytoestrogens include:

  • Red clover
  • Alfalfa
  • Hops (what beer is made from)
  • Liquorice
  • Turmeric

How plant estrogens work in the human body

Phytoestrogens bind to certain estrogen receptors in select tissues, activating or down-regulating the response of cells.

Breast and uterine tissue have the most ER-alpha estrogen receptors, while metabolic processes for the cardiovascular system and bones tend towards ER-beta receptors.

With other factors in play, the impacts of estrogens can be estrogenic or anti-estrogenic. In breast and uterine tissue, ER alpha receptors are downregulated by phytoestrogens, which may explain the possible anti-cancer benefits.

Phytoestrogens may also impact the balance of estrogen metabolites (the end result of estrogen metabolism), of which three are unfavourable to the body (16 alpha-hydroxy estrone, 4-hydroxy estradiol and 4-hydroxy estrone) and one favourable (2-hydroxy estrone).

Phytoestrogens may protect against cancer in the prostate​4​​, breast and uterus (and others)​5​ and may offer protection against heart disease and osteoporosis. Soybeans contain multiple anticarcinogens, with isoflavones noteworthy due to soy being the only significant dietary source.

Phyto-oestrogens and the thyroid

Isoflavones in soy and flavonoids from other plants inhibit thyroid peroxidase, an enzyme involved in thyroid hormone synthesis. High intake of phyto-oestrogens may result in worsening hypothyroidism or goitre in iodine-deficient individuals or those with hypothyroidism.​4​

Iodine deficiency increases the thyroid-blocking impact of soy, with iodine reversing this process.

How to use soy products for their phytoestrogens

In postmenopause, phytoestrogens can play a role alongside the adrenals in adding to the overall estrogenic effect on the body, helping to relieve genitourinary symptoms of menopause (GSM) – dry, easily irritated or damaged vaginal and vulvar tissue, urinary incontinence, etc.

We also use phytoestrogens in vaginal treatments such as Fennelope fennel pessaries for a local effect, which has been shown to thicken vaginal epithelial cells​5​. This thickening reduces the vulnerability of cells and can help provide much-needed glycogen in vaginal cells to support protective vaginal flora.

How soy is helpful in other ways

Soy protein can be helpful in some people as a source of complete protein, as soybeans contain all essential amino acids.

People with a history of hormone-related cancers (breast, ovarian, prostate) may benefit from a low animal fat diet and future protection from endogenous estrogens.

Regular intake of soy products can also decrease ‘bad’ cholesterol (low-density lipoproteins or LDL cholesterol) by as much as 10%, with every 1% drop equalling around a 2% drop in heart disease risk. This is significant. The FDA determined that diets with four daily soy servings can reduce levels of low-density lipoproteins.

Soy products may be a valuable dietary addition for some people, beyond the potential benefits for vaginal health.

References

  1. 1.
    Setchell KDR. Soy Isoflavones—Benefits and Risks from Nature’s Selective Estrogen Receptor Modulators (SERMs). Journal of the American College of Nutrition. Published online October 2001:354S-362S. doi:10.1080/07315724.2001.10719168
  2. 2.
    Mazur W, Adlercreutz H. Naturally occurring oestrogens in food. Pure and Applied Chemistry. Published online September 1, 1998:1759-1776. doi:10.1351/pac199870091759
  3. 3.
    Thompson LU, Boucher BA, Liu Z, Cotterchio M, Kreiger N. Phytoestrogen Content of Foods Consumed in Canada, Including Isoflavones, Lignans, and Coumestan. Nutrition and Cancer. Published online July 2006:184-201. doi:10.1207/s15327914nc5402_5
  4. 4.
    Doerge DR, Sheehan DM. Goitrogenic and estrogenic activity of soy isoflavones. Environmental Health Perspectives. Published online June 2002:349-353. doi:10.1289/ehp.02110s3349
  5. 5.
    Yaralizadeh M, Abedi P, Najar S, Namjoyan F, Saki A. Effect of Foeniculum vulgare (fennel) vaginal cream on vaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled trial. Maturitas. Published online February 2016:75-80. doi:10.1016/j.maturitas.2015.11.005


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