Review: Estrace vaginal oestrogen cream

Estrace is an oestrogen-based vaginal cream available only by prescription used to treat the symptoms of vaginal atrophy due to menopause or a lack of oestrogen (for example after breast cancer treatments).

Symptoms of moderate to severe dryness, itching and burning in and around the vagina, as part of the genitourinary symptoms of menopause (GSM) and atrophic vaginitis. This form of oestrogen can be dangerous, so we advise using an oestriol (E3) form of oestrogen, which doesn’t impact blood oestrogens, but works the same way.

Estrace should be used with the lowest possible dose to get the results you require, and only use this product for as long as needed. Only use it in and around the vagina.

Cost of Estrace

Estrace can be expensive, costing $286 per 42.5 grams of cream. It may not be available via insurance or Medicare.


  • Estrace is a plant-derived phyto-oestrogen product
  • Oestradiol (E2) USP 0.01%
  • Purified water
  • Propylene glycol
  • Stearyl alcohol
  • White ceresin wax
  • Mono- and diglycerides
  • Hypromellose 2208 (4000 cps)
  • Sodium lauryl sulfate
  • Methylparaben
  • Edetate disodium
  • Tertiary butylhydroquinone

Safety of Estrace

E2 (oestradiol) is a form of oestrogen that affects your blood levels of oestrogen, and can contribute to oestrogen-dependent cancers. Once you hit menopause, the lack of ovulation means there is no progesterone to push back against the oestrogen, which means oestrogen is allowed to roam free in your blood without impedance.

This can be very dangerous, so consider using an oestriol (E3) product, since the E3 form of oestrogen does not affect blood levels and is not believed to contribute to cancers, but has the same impact on vaginal tissues.

Side-effects of Estrace

  • Headaches
  • Breast tenderness
  • Irregular vaginal bleeding or spotting
  • Stomach or abdominal cramps
  • Bloating
  • Nausea
  • Hair loss
  • Vaginal burning, irritation and itching

Who should not use Estrace

  • Anyone with unusual vaginal bleeding, those with certain cancers, or anyone who has had a stroke or heart attack, blood clots or liver issues should not use Estrace.
  • Do not use if you are pregnant
  • Check for known allergens

Original price was: USD $9.95.Current price is: USD $0.00. ex GST/VAT/TAX
Original price was: USD $9.99.Current price is: USD $0.00. ex GST/VAT/TAX
Jessica Lloyd - Vulvovaginal Specialist Naturopathic Practitioner, BHSc(N)

Jessica is a degree-qualified naturopath (BHSc) specialising in vulvovaginal health and disease, based in Melbourne, Australia.

Jessica is the owner and lead naturopath of My Vagina, and is a member of the:

  • International Society for the Study of Vulvovaginal Disease (ISSVD)
  • International Society for the Study of Women's Sexual Health (ISSWSH)
  • National Vulvodynia Association (NVA) Australia
  • New Zealand Vulvovaginal Society (ANZVS)
  • Australian Traditional Medicine Society (ATMS)