How to use InterFase or InterFase Plus orally for gut biofilms (Killing BV)

InterFase Plus is a biofilm enzyme blend designed to break down biofilms created by bacteria that cause bacterial vaginosis (BV), aerobic vaginitis (AV) and Candida yeast infections. InterFase Plus can be used orally and vaginally. These instructions are for using InterFase Plus orally for gut biofilms.

You can use InterFase Plus as a vaginal or penile biofilm buster in a douche.

Biofilm treatments require care, so read all the safety information and reach out for help if you need it.

(6) USD $57.95

Dissolve BV, AV and yeast biofilms through the digestive tract and vagina. 120 caps.

(3) USD $69.95

Target disruptive bacteria and biofilms from the inside out.

This product has multiple variants. The options may be chosen on the product page

What is InterFase Plus?

InterFase is a set of specific enzymes that have been shown in the lab to break down the biofilm matrix of Gardnerella vaginalis, Candida albicans, and other harmful, biofilm-creating microbes.

Important note on using biofilm enzymes

Everyone is different, so take care, read all the instructions, and get help from an experienced healthcare provider if you fit into the categories below.

People who should use InterFase or InterFase Plus under medical guidance:

  • Diabetics and persons with blood glucose dysregulation
  • Those taking anticoagulants, anti-DPP-IV medications, oral hypoglycemic agents, or insulin
  • Those with gastritis, active peptic ulcers, gastroesophageal reflux disorder, or known damage to the gastrointestinal mucosa
  • Those with known allergies to Aspergillus organisms, though non-specific yeast or mould allergies, do not necessarily preclude the use of fungal-based enzymes.
  • Lysozyme is derived from egg white protein and is highly purified; however, this product may not be appropriate for persons allergic to egg white.
  • Anyone pregnant or breastfeeding should consult with a healthcare provider

Disruptive biofilms make treatments trickier

Many bacteria and yeast create biofilms, which can block protective flora by changing the environment to favour disruptive bacteria. These biofilms appear anywhere these microbes live: digestive system, mouth, vagina, the floor of your shower.

Signs of unhealthy digestive biofilms

People with chronic, ill-defined health conditions who don’t respond well to treatments may find they have a deeper microbial problem that needs addressing before they can get well.

Warnings about the biofilm matrix dissolving

Be gentle. A practitioner may be useful for guidance if you have a chronic illness or a complex health history. InterFase Plus is not going to be simple for everyone who uses it.

InterFase can sometimes make you feel unwell because it’s working. It’s not dangerous by itself per se (it’s enzymes), but if you feel unwell when using biofilm treatments, it means you have a biofilm problem that is unravelling – which is good. But, some people need to go slower or get support during this process.

If you do not have a biofilm problem, the product just won’t do anything at all.

InterFase Plus dosage, timing, and how it could feel

  1. Start slow, taking two tablets on an empty stomach each day for three days, and see how you feel.
  2. Once you understand how your body is going to respond to the enzymes, increase your dose up to a maximum of eight capsules per day (as indicated on the jar or as prescribed), taken in divided doses (four capsules twice daily).
  3. If you have a strong reaction, drop the dose to one tablet every two days, and work up from there as you feel comfortable.
  4. InterFase Plus side effects are dose-dependent, so drop back/increase as necessary. Do not exceed the recommended dose on the label.

Smooth teeth – plaque is a biofilm!

Plaque on your teeth is also a biofilm, and as a result, InterFase may cause plaque to come off your teeth. It’s not your enamel. The speed at which plaque is removed may be a reasonable indicator of how quickly or slowly it is working in your intestine and vagina.

Unless you’re plaque-free (good for you!), you can use your tongue to feel your teeth as you make your way through your treatment and feel them getting smoother.

Using antimicrobials and probiotics with InterFase Plus

The biofilm matrix contains microbes (bacteria, yeast, fungi, viruses) that are liberated when their biofilm shelter is dissolved.

Liberated bacteria, viruses and fungi can cause infection-like symptoms or even a fresh infection (like a cold or flu). Giving them no place to hide means they are on the hunt for a new home and can cause small infections on their way. This result is normal but can be uncomfortable and inconvenient!

InterFase does not kill bacteria.

Antimicrobials may be a useful adjunct to your biofilm treatment, which could include antibiotics (if you have already been prescribed these), herbal medicine such as the BV or AV Oral Herbal Formulas or food-based antimicrobials like raw garlic.

(3) USD $69.95

Target disruptive bacteria and biofilms from the inside out.

This product has multiple variants. The options may be chosen on the product page
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Starts working quickly, supporting resolution of UTI symptoms within 30 minutes.

This product has multiple variants. The options may be chosen on the product page

Milk kefir and gut-specific probiotics help compete with the liberated microbes and replace their position as they fall away.

Milk kefir oral and penile treatment (Killing BV)

We explain how men should do the milk kefir penis and oral treatments as part of the Killing BV treatment for men, with clear instructions.

Milk kefir oral and vaginal BV treatment for vaginas (Killing BV)

How to use milk kefir orally and vaginally to get rid of BV and biofilms, maximising your treatments and optimising your chances of getting rid of your BV forever. LOGIN This is EXCLUSIVE MEMBERSHIP-only content Login or obtain your membership below, and we'll see you back here soon! Killing BV - Vagina Treatment Guide   To access this content, you must be enrolled in the ({products}). Log in

How to take care of your milk kefir

Learn how to take care of your milk kefir grains and get the most out of them every day. Clear instructions and FAQs.

What to do at the same time as your InterFase treatment

  • Take a high-quality digestive probiotic or home-made milk kefir
  • Use the Oral BV or AV Herbal Formulas
  • Eat a plant-based diet high in fibre
  • Stay hydrated
  • Rest and relax, plan ahead
  • Keep your bowels moving to remove the bacteria as quickly as possible!
Review: Klaire Labs InterFase and InterFase Plus

InterFase and InterFase Plus is a biofilm enzyme treatment taken orally to reduce pathogenic biofilms throughout the digestive tract.

Using InterFase Plus as a vaginal douche (Killing BV)

We discuss the methods you'll need to use InterFase Plus vaginally and on the penis as part of Killing BV treatments plans.

Using InterFase Plus – penis (Killing BV)

We explain how to use InterFase or InterFase Plus as a penis treatment for BV-related biofilms in men, with clear instructions for dosage and application. LOGIN This is EXCLUSIVE MEMBERSHIP-only content Login or obtain your membership below, and we'll see you back here soon! Killing BV - Vagina Treatment Guide   To access this content, you must be enrolled in the (Killing BV: Penis Treatment Program). Log in

Note on biofilm enzymes

NOTE: If you’re looking for a systemic biofilm treatment, we have products that are more effective than InterFase Plus for biofilms outside of the digestive tract (i.e. for reaching the vagina and urinary tract) – Aunt Vadge’s Biofilm Enzyme Blend and nattokinase. (Do not use Serralase or Kirkman’s Biofilm Defense).

(3) USD $39.95

Biofilm agent, anti-inflammatory, antioxidant, improves immune function, and so much more.

(6) USD $57.95

Dissolve BV, AV and yeast biofilms through the digestive tract and vagina. 120 caps.

(3) USD $64.95

Degrade gut and vaginal biofilms, and encourage healthy digestion and gut microbiome.

(2) USD $39.95

Degrades fibrin, the mesh of biofilms, for support in treatment-resistant vaginal infections like BV.

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Biofilm enzyme blend treatment to support clearance of systemic biofilms and reduce inflammation.

More information on biofilms

Aunt Vadge: How do oral biofilm enzymes get to the vagina?

Ever wondered how an enzyme taken by mouth can impact vaginal biofilms? Aunt Vadge explains!

Bacterial biofilms: what is extraceullar DNA? (EDNA)

How bacteria build their fortresses: the secrets of extracellular DNA and how they are used to make biofilms/

Impact of Cinnamomum on Pseudomonas aeruginosa biofilms

Cinnamomum, one of the active constituents of cinnamon, has strong antibacterial and antibiofilm activity against P. aeruginosa.



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Support recovery from vaginal yeast infections/thrush and restore a protective vaginal microbiome.

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Replenish healthy lactobacilli species the easy way - feed them their favourite food, lactulose! Comes with capsules.

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